Sensory processing in olfactory systems is organized across olfactory bulb glomeruli, wherein axons of peripheral sensory neurons expressing the same olfactory receptor co-terminate to transmit receptor-specific activity to central neurons. Understanding how receptors map to glomeruli is therefore critical to understanding olfaction. High-throughput spatial transcriptomics is a rapidly advancing field, but low-abundance olfactory receptor expression within glomeruli has previously precluded high-throughput mapping of receptors to glomeruli in the mouse. Here we combined sequential sectioning along the anteroposterior, dorsoventral, and mediolateral axes with target capture enrichment sequencing to overcome low-abundance target expression. This strategy allowed us to spatially map 86% of olfactory receptors across the olfactory bulb and uncover a relationship between OR sequence and glomerular position.
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Silverman, Justin D. ; Roche, Kimberly ; Mukherjee, Sayan ; David, Lawrence A. ( , Computational and Structural Biotechnology Journal)
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Shenhav, Liat ; Furman, Ori ; Briscoe, Leah ; Thompson, Mike ; Silverman, Justin D. ; Mizrahi, Itzhak ; Halperin, Eran ; Bonneau, Richard A. ( , PLOS Computational Biology)
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Washburne, Alex D. ; Silverman, Justin D. ; Morton, James T. ; Becker, Daniel J. ; Crowley, Daniel ; Mukherjee, Sayan ; David, Lawrence A. ; Plowright, Raina K. ( , Ecological Monographs)
